Posted by BeauHD from Slashdot
From the promising-results department: A groundbreaking stem cell treatment developed by Vertex Pharmaceuticals has allowed 10 out of 12 patients with severe type 1 diabetes to stop insulin therapy after one year. While the trial included some side effects and two unrelated deaths, the results mark a major step forward and have progressed to phase 3 clinical testing. ScienceAlert reports: The pancreas's islet cells are responsible for maintaining most of our bodies' insulin levels. Donor transplants of healthy versions of these cells have shown promise in treating type 1 diabetes in the past, but multiple donors are required, and donors are rare. So University of Toronto surgeon Trevor Reichman and colleagues infused 12 patients with islet cells derived from human stem cells in a treatment known as zimislecel. The patients also received immunosuppressive treatment before and after their zimislecel infusion. The islets not only produced insulin inside their bodies, but they did so at safe levels, reducing the patients' dependence on costly doses of insulin. "These findings showed that zimislecel islet cells were functional and self-regulated appropriately," the researchers write in their paper.
The mild to moderate side-effects, including decreased kidney function and the anticipated drop in immune cells, were all linked with the immunosuppressive therapy. Sadly, two additional participants died during the trial; one from an infection arising from surgery and the other from complications due to an unrelated condition. As there were no serious adverse events attributed to the new islet cell therapy, the clinical trials are have progressed into phase 3. "These findings provide evidence that pancreatic islets can be effectively produced from pluripotent stem cells and used to treat type 1 diabetes," Reichman and team conclude. The research has been published in the journal NEJM.
Posted by BeauHD from Slashdot
From the land-down-under-16 department: Australia's eSafety Commissioner has urged the government to deny YouTube an exemption from upcoming child safety regulations, citing research showing it exposes more children to harmful content than any other platform. YouTube pushed back, calling the commissioner's stance inconsistent with government data and parental feedback. "The quarrel adds an element of uncertainty to the December rollout of a law being watched by governments and tech leaders around the world as Australia seeks to become the first country to fine social media firms if they fail to block users aged under 16," reports Reuters. From the report: The centre-left Labor government of Anthony Albanese has previously said it would give YouTube a waiver, citing the platform's use for education and health. Other social media companies such as Meta's Facebook and Instagram, Snapchat, and TikTok have argued such an exemption would be unfair. eSafety Commissioner Julie Inman Grant said she wrote to the government last week to say there should be no exemptions when the law takes effect. She added that the regulator's research found 37% of children aged 10 to 15 reported seeing harmful content on YouTube -- the most of any social media site. [...]
YouTube, in a blog post, accused Inman Grant of giving inconsistent and contradictory advice, which discounted the government's own research which found 69% of parents considered the video platform suitable for people under 15. "The eSafety commissioner chose to ignore this data, the decision of the Australian Government and other clear evidence from teachers and parents that YouTube is suitable for younger users," wrote Rachel Lord, YouTube's public policy manager for Australia and New Zealand.
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Posted by from MMO Champion
Dastardly Duos Week 4: Tyrannotort Mount, Cosmetic Staff & Winner's Podium Upgrades
Week 4 of the Dastardly Duos event is here! In this post, we quickly go over how to unlock this week's rewards:
Tyrannotort's Treat,
Dastardly Pinchzapper, and
Winner's Podium toy upgrades.
Take the quest Week 4: They've Heard of You from Vinnie Sweets.
Win the Dastardly Duos match to complete the weekly quest and turn it in to gain the
Average Item Level measure for your
Winner's Podium.
Speak with Wodim the Troll-Servant to purchase the newly unlocked rewards:
New Mount:
Tyrannotort's Treat
New Cosmetic Staff:
Dastardly Pinchzapper
Players can unlock the last four remaining podium upgrades required for the
Winner's Podium achievement starting with Week 4 of the Dastardly Duos world event. The upgrades are random drops, there are no special requirements. Simply clear the trash, defeat the bosses, loot the Prize Chest, and hope for upgrades.
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From the one-cup-away-from-immortality department: alternative_right shares a report from Phys.Org: In new research published by scientists studying fission yeastâ"a single-celled organism surprisingly similar to human cellsâ"researchers found that caffeine affects aging by tapping into an ancient cellular energy system. A few years ago, the same research team found that caffeine helps cells live longer by acting on a growth regulator called TOR (target of rapamycin). TOR is a biological switch that tells cells when to grow, based on how much food and energy is available. This switch has been controlling energy and stress responses in living things for over 500 million years. But in their latest study, the scientists made a surprising discovery: Caffeine doesn't act on this growth switch directly. Instead, it works by activating another important system called AMPK, a cellular fuel gauge that is evolutionarily conserved in yeast and humans.
"When your cells are low on energy, AMPK kicks in to help them cope," explains Dr. Charalampos (Babis) Rallis, Reader in Genetics, Genomics and Fundamental Cell Biology at Queen Mary University of London, the study's senior author. "And our results show that caffeine helps flip that switch." Interestingly, AMPK is also the target of metformin, a common diabetes drug that's being studied for its potential to extend human lifespan together with rapamycin. Using their yeast model, the researchers showed that caffeine's effect on AMPK influences how cells grow, repair their DNA, and respond to stress -- all of which are tied to aging and disease. The study has been published in the journal Microbial Cell.
Posted by BeauHD from Slashdot
From the black-hole-of-energy-use department: An anonymous reader quotes a report from 404 Media: A massive data center for Meta's AI will likely lead to rate hikes for Louisiana customers, but Meta wants to keep the details under wraps. Holly Ridge is a rural community bisected by US Highway 80, gridded with farmland, with a big creek -- it is literally named Big Creek -- running through it. It is home to rice and grain mills and an elementary school and a few houses. Soon, it will also be home to Meta's massive, 4 million square foot AI data center hosting thousands of perpetually humming servers that require billions of watts of energy to power. And that energy-guzzling infrastructure will be partially paid for by Louisiana residents.
The plan is part of what Meta CEO Mark Zuckerberg said would be "a defining year for AI." On Threads, Zuckerberg boasted that his company was "building a 2GW+ datacenter that is so large it would cover a significant part of Manhattan," posting a map of Manhattan along with the data center overlaid. Zuckerberg went on to say that over the coming years, AI "will drive our core products and business, unlock historic innovation, and extend American technology leadership. Let's go build! " What Zuckerberg did not mention is that "Let's go build" refers not only to the massive data center but also three new Meta-subsidized, gas power plants and a transmission line to fuel it serviced by Entergy Louisiana, the region's energy monopoly.
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Posted by BeauHD from Slashdot
From the what-to-expect department: The Register's Simon Sharwood reports: Huawei's chairman Xu Zhijun -- aka Eric Xu -- has called out China's enormous lead in fiber-to-the-room (FTTR) installations. Speaking at last week's Mobile World Congress event in Shanghai, Xu shared his views on the telecommunications industry's future growth opportunities and said by the end of 2025 China will be home to 75 million FTTR installations -- but just 500,000 exist outside the Middle Kingdom. Xu said FTTR will benefit businesses by increasing their internet connection speeds, helping them address spotty Wi-Fi coverage, allowing them to deploy tech in more places, and therefore creating more opportunities to adopt productivity-boosting devices and services. FTTR will also help carriers to sell more expensive packages, he said. Xu also urged telecom carriers to target high-growth user groups like delivery riders and livestream influencers, citing their above-average data consumption and revenue potential. Delivery riders, who will make up 5% of the global workforce by 2030, use four times more voice minutes and double the data of average users, while influencers generate five times the data usage and four times the revenue.
He also pushed for greater collaboration between carriers and platforms to deliver more high-res video content, and called for improved efficiency in networking equipment and device power use. "Xu said Huawei is here to help carriers deliver any of the scenarios he mentioned," concludes Sharwood. "And of course it is, because the Chinese giant has a thriving business selling to telcos -- or at least to telcos beyond the liberal democracies that have largely decided Huawei's close ties with Beijing mean the company and its products represent an unacceptable threat to the operation of critical infrastructure."
'This HAZMAT container contains radioactive material with activity of one becquerel.' 'So, like, a single banana slice?' 
