Posted by msmash from Slashdot
From the leap-forward department: Researchers have hailed another "leap forward" for AI after Google DeepMind unveiled the latest version of its AlphaFold program, which can predict how proteins behave in the complex symphony of life. From a report: The breakthrough promises to shed fresh light on the biological machinery that underpins living organisms and drive breakthroughs in fields from antibiotics and cancer therapy to new materials and resilient crops. "It's a big milestone for us," said Demis Hassabis, the chief executive of Google DeepMind and the spin-off, Isomorphic Labs, which co-developed AlphaFold3. "Biology is a dynamic system and you have to understand how properties of biology emerge through the interactions between different molecules."

Earlier versions of AlphaFold focused on predicting the 3D structures of 200m proteins, the building blocks of life, from their chemical constituents. Knowing what shape a protein takes is crucial because it determines how the protein will function -- or malfunction -- inside a living organism. AlphaFold3 was trained on a global database of 3D molecular structures and goes a step further by predicting how proteins will interact with the other molecules and ions they encounter. When asked to make a prediction, the program starts with a cloud of atoms and steadily reshapes it into the most accurate predicted structure. Writing in Nature, the researchers describe how AlphaFold3 can predict how proteins interact with other proteins, ions, strands of genetic code, and smaller molecules, such as those developed for medicines. In tests, the program's accuracy varied from 62% to 76%.
Posted by Willa Rowe from Kotaku
The first step to a video game becoming a success is finding the right audience. And while that’s easier for AAA games backed by big companies with equally big marketing budgets, indie games have a harder time getting the word out to the right players. This is why a new trend on X (formerly Twitter) is already being…

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Posted by Diego Argüello from Kotaku
Hades 2 tasks you an array of bite-sized crafting mechanics. As we mentioned in our tips guide, these tasks don’t demand as much busywork as you might think. That said, you’re bound to find certain materials, like Fate Fabric, to be frustratingly elusive if you don’t know where to look. We know where to look!

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Posted by Claire Jackson from Kotaku
One of Metal Gear Solid’s ultimate bosses is the massive walking battle tank known as Metal Gear Rex. Rex is one of the tougher boss fights of the game, and little else is more frustrating than repeatedly dying to a late-game boss when you’re so, so close to wrapping up.

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Posted by Eric Schulkin from Kotaku
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Posted by msmash from Slashdot
From the closer-look department: Full repairs to three submarine internet cables damaged in the Red Sea in February are being held up by disputes over who controls access to infrastructure in Yemeni waters. From a report: The Yemeni government has granted permits for the repair of two out of three cables, but refused the third because of a dispute with one of the cable's consortium members. Repairs to the Seacom and EIG cables have been approved, but the consortium that runs AAE-1, which includes telecommunications company TeleYemen, was not granted a permit by Yemen's internationally recognized government, according to documents seen by Bloomberg.

Three out of more than a dozen cables that run through the Red Sea, a critical route for connecting Europe's internet infrastructure to Asia's, were knocked offline by the Houthi-sunk Rubymar vessel in late February. Although the telecommunications data that passes along the damaged cables was re-routed, the incident highlighted the vulnerability of critical subsea infrastructure and the challenges of making repairs in a conflict zone. The dispute over the third cable derives from the split political control of TeleYemen, the country's sole telecommunications provider, a reflection of the country's broader geopolitical divisions.
Posted by msmash from Slashdot
From the how-about-that department: Less than 24 hours after Apple held a special event to unveil the new, record-thin (0.20 inch, the thinnest Apple device yet) iPad Pro with M4 chip inside, which the company says is optimized for AI, it is facing a loud and fast-spreading public backlash to one of its new marquee video advertisements promoting the device -- a spot called "Crush." VentureBeat: The video features a giant, industrial hydraulic press machine -- a device category famous for appearing in viral videos over the last decade-and-a-half -- literally pressing down upon and destroying dozens of other objects and creative instruments, from trumpets to cans of paint. The ad concludes with the press lifting to reveal these objects have somehow been transformed into a new iPad Pro. The metaphor and messaging is pretty obvious: the iPad Pro can subsume and replace all these older legacy instruments and technologies inside of it, and all in a more portable, sleek, and more powerful form factor than ever before.

It's analogous to similar observations and advertisements other fans and creatives have made in the past about how PCs and smartphones replaced nearly all the individual gadgets -- stereo radios/boom boxes, journals, calculators, drawing pads, typewriters, video cameras -- of yore by offering many of their same core capabilities in a smaller, unified, more portable form factor. [...] People are revolted by the bluntness of Apple's metaphor, the destruction of beloved traditional instruments and objects which people hold in high esteem and affix intangible value to for their creative potential, and the overarching and perhaps unintentional messaging that Apple wants to literally flatten creativity and violently crush the creative tools of yesterday in favor of a multi-hundred dollar piece of luxury technology whose operating system and ecosystem of applications it tightly controls and restricts.
Posted by Kenneth Shepard from Kotaku
Sometimes, you get blatant reminders of how much disregard big tech has for, well, everything. Whether that’s exorbitant spending on acquisitions, layoffs of hundreds to thousands of people, and refusing to release or delist its employees’ hard work for a tax write-off. But now and then, you get all that callousness…

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Posted by Diego Argüello from Kotaku
Hades 2 has an array of additions to discover, from incantations to new bosses to take down. Tarot Arcana cards are part of this wave of features, basically repurposing the Mirror of Night from the first game into an entirely new system.

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Posted by John Walker from Kotaku
Harvey Smith, the now-former studio director at Arkane Austin, has taken to X/Twitter to express his feelings about Microsoft’s sudden and shocking closure of the beloved developer, alongside three other Bethesda-adjacent studios, Tango Gameworks, Alpha Dog Games, and Roundhouse Games. The team that brought us Dishonor…

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Posted by msmash from Slashdot
From the closer-look department: AstraZeneca said on Tuesday it had initiated the worldwide withdrawal of its COVID-19 vaccine due to a "surplus of available updated vaccines" since the pandemic. From a report: The company also said it would proceed to withdraw the vaccine Vaxzevria's marketing authorizations within Europe. "As multiple, variant COVID-19 vaccines have since been developed there is a surplus of available updated vaccines," the company said, adding that this had led to a decline in demand for Vaxzevria, which is no longer being manufactured or supplied. According to media reports, the Anglo-Swedish drugmaker has previously admitted in court documents that the vaccine causes side-effects such as blood clots and low blood platelet counts.
Posted by Black Convoy from TFW2005


Following our first out-of-the-box look at some new 40th Anniversary Transformers Funko Pop figures, now via @drj_pops on Instagram we have our first in-box image of Optimus Prime, Megatron, Astrotrain and a new Blaster figure. These new Funko Pop Transformers got a new toy-inspired deco and design. We still have no concrete information about price or release date, but stay tuned with this space for more updates. See the image after the jump and then share your impressions on the 2005 Boards!

The post 40th Anniversary Transformers Funko Pop Optimus Prime, Megatron, Astrotrain & Blaster In-Box Images appeared first on Transformer World 2005 - TFW2005.COM.
Posted by Ethan Gach from Kotaku
An original prototype of Nintendo’s Super Famicom, Japan’s (superior) version of the SNES, is currently up for auction and recent bids have already pushed the grey piece of gaming history north of $3.2 million. The “god-tier” nostalgia bait shows the market for retro collectibles can still be all over the place.

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Posted by Kenneth Shepard from Kotaku
In 2011, Warner Bros. and WaterTower Music put together a compilation album for Rocksteady’s open-world superhero game Batman: Arkham City. The album featured some pretty big names like Panic! at the Disco, Blaqk Audio, and Serj Tankian, all contributing original songs meant to pay tribute to the caped crusader. Among…

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Posted by msmash from Slashdot
From the shape-of-things-to-come department: The Biden administration is poised to open up a new front in its effort to safeguard U.S. AI from China with preliminary plans to place guardrails around the most advanced AI models, the core software of artificial intelligence systems like ChatGPT, Reuters reported Wednesday. From the report: The Commerce Department is considering a new regulatory push to restrict the export of proprietary or closed source AI models, whose software and the data it is trained on are kept under wraps, three people familiar with the matter said. Any action would complement a series of measures put in place over the last two years to block the export of sophisticated AI chips to China in an effort to slow Beijing's development of the cutting edge technology for military purposes. Even so, it will be hard for regulators to keep pace with the industry's fast-moving developments.

Currently, nothing is stopping U.S. AI giants like Microsoft-backed OpenAI, Alphabet's Google DeepMind and rival Anthropic, which have developed some of the most powerful closed source AI models, from selling them to almost anyone in the world without government oversight. Government and private sector researchers worry U.S. adversaries could use the models, which mine vast amounts of text and images to summarize information and generate content, to wage aggressive cyber attacks or even create potent biological weapons. To develop an export control on AI models, the sources said the U.S. may turn to a threshold contained in an AI executive order issued last October that is based on the amount of computing power it takes to train a model. When that level is reached, a developer must report its AI model development plans and provide test results to the Commerce Department.
Posted by Black Convoy from TFW2005


The Shizuoka Hobby Show 2024 surprised us last night with several unexpected Takara Tomy reveals and updates. We have for you a round up with new images of the figures revealed yesterday plus some other new items. Images come thanks to friend site and sponsor Robotkingdom, Hobby Dengeki, and Twitter users @famima56125, and @digitamin Transformers 40 Anniversary T40A Bumblebee – A new special premium redeco of the Masterpiece Movie MPM-03 Bumblebee featuring a new yellow tone, improved stripes and other details. Bingo Sports x Transformers – Amazing display of this new collaboration with Japanese car collectible » Continue Reading.

The post Shizuoka Hobby Show 2024 – Takara Tomy New Reveals & More appeared first on Transformer World 2005 - TFW2005.COM.
Posted by BeauHD from Slashdot
From the cease-and-desist department: An anonymous reader quotes a report from MSN: The US has revoked licenses allowing Huawei to buy semiconductors from Qualcomm and Intel, according to people familiar with the matter, further tightening export restrictions against the Chinese telecom equipment maker. Withdrawal of the licenses affects US sales of chips for use in Huawei phones and laptops, according to the people, who discussed the move on condition of anonymity. House Foreign Affairs Committee Chairman Michael McCaul confirmed the administration's decision in an interview Tuesday. He said the move is key to preventing China from developing advanced AI. "It's blocking any chips sold to Huawei," said McCaul, a Texas Republican who was briefed about the license decisions for Intel and Qualcomm. "Those are two companies we've always worried about being a little too close to China."

While the decision may not affect a significant volume of chips, it underscores the US government's determination to curtail China's access to a broad swathe of semiconductor technology. Officials are also considering sanctions against six Chinese firms that they suspect could supply chips to Huawei, which has been on a US trade restrictions list since 2019. [...] Qualcomm recently said that its business with Huawei is already limited and will soon shrink to nothing. It has been allowed to supply the Chinese company with chips that provide older 4G network connections. It's prohibited from selling ones that allow more advanced 5G access.
Posted by Moises Taveras from Kotaku
Hades 2 is now available in Early Access on PC via Steam and the Epic Games Store and let me tell you folks, it’s great to be back in Hell. The highly anticipated title is just as fun as the first game—maybe even more so—and it has an intriguing story that I can’t wait to unravel during its Early Access period. It’s…

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Crow Country: The Kotaku Review 2024-05-08 06:20:02
Posted by Willa Rowe from Kotaku
Playing retro-inspired games is like returning to a beloved theme park as an adult. Instinctively knowing where to go first, remembering what it was like to be there as a child —it plays to a very specific kind of nostalgia. Retro-inspired games often include familiar mechanics, recognizable art styles, and tropes of…

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Posted by msmash from Slashdot
From the closer-look department: An anonymous reader shares a report: According to data analyzed by Morgan Stanley and Pitchbook, the number of active venture capital firms worldwide surged from 2014 levels, more than doubling by 2021, before sharply contracting to below 2014 figures in a stunning reversal.
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